The Museum is directed by Michele Lanzinger, who holds a degree Geology and a PhD in Anthropological Sciences. His area of research relates to the human population of the Alps in prehistoric times, an area in which he has carried out field studies and has published numerous scientific articles.

He was appointed curator of the Section of Geology and Paleontology of the Museum of Human Sciences in 1988, and became director in 1992. Since then Lanzinger has developed an intensive program of temporary exhibitions which led to a significant increase in the number of visitors to the Museum. He promoted the Museum's teaching program, which is now used by 70% of Trentino's school population (figure from 2010).

From 1997 to 2004 he was president of the National Association of Science Museums (ANMS). Since 2011, he is the only Italian representative on the Board of ECSITE, the European network of science centres and museums.